A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

• Arno Verlee,
• Thomas Heugebaert,
• Tom van der Meer,
• Pavel I. Kerchev,
• Frank Van Breusegem and
• Christian V. Stevens

Beilstein J. Org. Chem. 2017, 13, 303–312, doi:10.3762/bjoc.13.33

• , 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues. Keywords: flow chemistry; medium-throughput synthesis; m-sulfamoylbenzamide analogues; Introduction Small

• conditions due to quasi-ideal mixing conditions. Medium-throughput synthesis To evaluate the flexibility of both processes, a range of molecules were synthesized on small scale. In total, 49 molecules could be readily used for a medium-throughput screening for pharmaceutical applications. The

• account but, the screening of these analogues should already give a good indication which compounds are of interest. Medium throughput synthesis if F2 are primary amines Between each sample a washing step with CH3CN was included to eliminate any side reaction of undesired amines in the system. For the